Article
Non-invasive detection of somatic mutations using next-generation sequencing in primary central nervous system lymphoma.
Oncotarget - 18 Jul 2017
Fontanilles Maxime, Marguet Florent, Bohers Élodie, Viailly Pierre-Julien, Dubois Sydney, Bertrand Philippe, Camus Vincent, Mareschal Sylvain, Ruminy Philippe, Maingonnat Catherine, Lepretre Stéphane, Veresezan Elena-Liana, Derrey Stéphane, Tilly Hervé, Picquenot Jean-Michel, Laquerrière Annie, Jardin Fabrice
Abstract excerpt
PURPOSE: Primary central nervous system lymphomas (PCNSL) have recurrent genomic alterations. The main objective of our study was to demonstrate that targeted sequencing of circulating cell-free DNA (cfDNA) released by PCNSL at the time of diagnosis could identify somatic mutations by next-generation sequencing (NGS). PATIENTS AND METHODS: PlasmacfDNA and matched tumor DNA (tDNA) from 25 PCNSL patients were...
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