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Article

MyD88 Mutation in Elderly Predicts Poor Prognosis in Primary Central Nervous System Lymphoma: Multi-Institutional Analysis.

World neurosurgery - 1 Apr 2018

Takano Shingo, Hattori Keiichiro, Ishikawa Eiichi, Narita Yoshitaka, Iwadate Yasuo, Yamaguchi Fumio, Nagane Motoo, Akimoto Jiro, Oka Hidehiro, Tanaka Satoshi, Sakata Mamiko, Matsuda Masahide, Yamamoto Tetsuya, Chiba Shigeru, Matsumura Akira

Abstract excerpt

BACKGROUND: Recent genetic analysis of primary central nervous system lymphoma (PCNSL) showed that the MyD88 L265P mutation, which is related to NF-κB signaling, was a genetic hallmark for PCNSL; thus it could serve as a genetic marker for diagnosis and a potential target for molecular therapy. However, the role of the MyD88 mutation in PCNSL has not been defined. In this study, we investigated the role of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29258950
DOI: 10.1016/j.wneu.2017.12.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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