Article
Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers.
PLoS genetics - 1 Mar 2021
Lesseur Corina, Ferreiro-Iglesias Aida, McKay James D, Bossé Yohan, Johansson Mattias, Gaborieau Valerie, Landi Maria Teresa, Christiani David C, Caporaso Neil C, Bojesen Stig E, Amos Christopher I, Shete Sanjay, Liu Geoffrey, Rennert Gadi, Albanes Demetrius, Aldrich Melinda C, Tardon Adonina, Chen Chu, Triantafillos Liloglou, Field John K, Teare Marion Dawn, Kiemeney Lambertus A, Diergaarde Brenda, Ferris Robert L, Zienolddiny Shanbeh, Lam Stephen, Olshan Andrew F, Weissler Mark C, Lacko Martin, Risch Angela, Bickeböller Heike, Ness Andy R, Thomas Steve, Le Marchand Loic, Schabath Matthew B, Wünsch-Filho Victor, Tajara Eloiza H, Andrew Angeline S, Clifford Gary M, Lazarus Philip, Grankvist Kjell, Johansson Mikael, Arnold Susanne, Melander Olle, Brunnström Hans, Boccia Stefania, Cadoni Gabriella, Timens Wim, Obeidat Ma'en, Xiao Xiangjun, Houlston Richard S, Hung Rayjean J, Brennan Paul
Abstract excerpt
Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC),...
Topics
- Alleles
- Biomarkers, Tumor
- Carcinoma, Squamous Cell
- Digestive System Neoplasms