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Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response

9 Feb 2022

Abstract excerpt

Legionella pneumophila is an intracellular bacterial pathogen that can cause a severe form of pneumonia in humans, a phenotype evolved through interactions with aquatic protozoa in the environment. Here, we show that L. pneumophila uses extracellular vesicles to translocate bacterial small RNAs (sRNAs) into host cells that act on host defence signalling pathways. The bacterial sRNA RsmY binds to the UTR of ddx58...

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PMID: 35140216
DOI: 10.1038/s41467-022-28454-x

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