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Article

Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload.

PloS one - 1 Jan 2017

Ohba Takayoshi, Watanabe Hiroyuki, Murakami Manabu, Iino Kenji, Adachi Takeshi, Baba Yoshihiro, Kurosaki Tomohiro, Ono Kyoichi, Ito Hiroshi

Abstract excerpt

Stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca2+ sensor, has been shown to control a Ca2+-dependent signal that promotes cardiac hypertrophy. However, whether STIM1 has adaptive role that helps to protect against cardiac overload stress remains unknown. We hypothesized that STIM1 deficiency causes a maladaptive response to pressure overload stress. We investigated STIM1 heterozygous KO...

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Source

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Identifiers

PMID: 29145451
DOI: 10.1371/journal.pone.0187950
PMCID: PMC5690472

Genes

STIM1
STIM2
TRPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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