Article
Pathophysiological significance of Stim1 mutation in sympathetic response to stress and cardiovascular phenotypes in SHRSP/Izm: In vivo evaluation by creation of a novel gene knock-in rat using CRISPR/Cas9.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 2 Jan 2021
Odongoo Batbayar, Ohara Hiroki, Ngarashi Davis, Kaneko Takehito, Kunihiro Yayoi, Mashimo Tomoji, Nabika Toru
Abstract excerpt
Genetic approach using rat congenic lines between SHRSP/Izm and WKY/Izm identified stromal interaction molecule 1 (Stim1), an essential component of store-operated Ca2+ entry (SOCE), as a promising candidate gene responsible for the exaggerated sympathetic response to stress in SHRSP. Since SHRSP has a nonsense mutation in Stim1 resulting in the expression of a truncated form of STIM1 that caused reduction of...
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