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Article

DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors.

Cell reports - 23 Jan 2024

Ostroverkhova Daria, Tyryshkin Kathrin, Beach Annette K, Moore Elizabeth A, Masoudi-Sobhanzadeh Yosef, Barbari Stephanie R, Rogozin Igor B, Shaitan Konstantin V, Panchenko Anna R, Shcherbakova Polina V

Abstract excerpt

Alterations in the exonuclease domain of DNA polymerase ε cause ultramutated cancers. These cancers accumulate AGA>ATA transversions; however, their genomic features beyond the trinucleotide motifs are obscure. We analyze the extended DNA context of ultramutation using whole-exome sequencing data from 524 endometrial and 395 colorectal tumors. We find that G>T transversions in POLE-mutant tumors predominantly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38219146
DOI: 10.1016/j.celrep.2023.113655
PMCID: PMC10830898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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