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Article

A panoply of errors: polymerase proofreading domain mutations in cancer.

Nature reviews. Cancer - 1 Feb 2016

Rayner Emily, van Gool Inge C, Palles Claire, Kearsey Stephen E, Bosse Tjalling, Tomlinson Ian, Church David N

Abstract excerpt

Although it has long been recognized that the exonucleolytic proofreading activity intrinsic to the replicative DNA polymerases Pol δ and Pol ε is essential for faithful replication of DNA, evidence that defective DNA polymerase proofreading contributes to human malignancy has been limited. However, recent studies have shown that germline mutations in the proofreading domains of Pol δ and Pol ε predispose to...

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PMID: 26822575
DOI: 10.1038/nrc.2015.12

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Click a neighbor to travelStep 1 · 12 closest

A panoply of errors: polymerase proofreading domain mutations in cancer.PMID 26822575Read ↗

Comparative Analysis of Somatic and Germline Polymerase Proofreading Deficiencies in Cancer: Molecular and Clinical ImplicationsSemantic proximity Read ↗

Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.Semantic proximity Read ↗

Replicative DNA polymerase mutations in cancer.Semantic proximity Read ↗

Beyond proofreading: POLD1 mutations as dynamic orchestrators of genomic instability and immune evasion in cancerSemantic proximity Read ↗

A common cancer-associated DNA polymerase ε mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading.Semantic proximity Read ↗

Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers.Semantic proximity Read ↗

From Subtle to Severe: Multiple Mechanisms Impair POLE and POLD1 Function leading to Distinct Effects on Mutation RatesSemantic proximity Read ↗

Cancer predisposition syndromes: lessons for truly precision medicine.Semantic proximity Read ↗

Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae.Semantic proximity Read ↗

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repairSemantic proximity Read ↗

DNA polymerase η mutational signatures are found in a variety of different types of cancer.Semantic proximity Read ↗

DNA polymerase epsilon catalytic subunit (POLE) in cancer: Implications for tumor biology and therapeutic strategies - A comprehensive review.Semantic proximity Read ↗

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