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Article

Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology.

mBio - 14 Nov 2017

Jones Jennifer E, Long Kristin M, Whitmore Alan C, Sanders Wes, Thurlow Lance R, Brown Julia A, Morrison Clayton R, Vincent Heather, Peck Kayla M, Browning Christian, Moorman Nathaniel, Lim Jean K, Heise Mark T

Abstract excerpt

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade. These include a recent outbreak in the Caribbean islands and the Americas that caused more than 1 million cases of viral arthralgia. Despite the major impact of CHIKV on global health, viral determinants that promote CHIKV-induced...

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Identifiers

PMID: 29138302
DOI: 10.1128/mBio.01456-17
PMCID: PMC5686535

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