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Article

A conserved in-frame stop codon acts as a multipotent defense mechanism in alphaviruses.

Science advances - 19 Jun 2026

Bhattacharya Tamanash, Freeman Tiia S, Alleman Eva M, Wang Fang, Chechik Lyuba, Emerman Michael, Myles Kevin M, Malik Harmit S

Abstract excerpt

Most alphaviruses maintain an in-frame opal stop codon that interrupts their nonstructural polyprotein (nsP) ORF between nsP3 and nsP4 in both vertebrate and insect hosts. We show that the nsP3 opal stop codon confers a replicative advantage to Sindbis virus (SINV) in RNAi-competent Aedes cells and mosquitoes but not in RNAi-deficient cells or mosquitoes. Mutation of the opal stop codon delays processing of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42308287
DOI: 10.1126/sciadv.aee6015
PMCID: PMC13274604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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