Article
Mutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine Design.
mBio - 21 Feb 2017
Taylor Adam, Liu Xiang, Zaid Ali, Goh Lucas Y H, Hobson-Peters Jody, Hall Roy A, Merits Andres, Mahalingam Suresh
Abstract excerpt
Mosquito-transmitted chikungunya virus (CHIKV) is an arthritogenic alphavirus of the Togaviridae family responsible for frequent outbreaks of arthritic disease in humans. Capsid protein, a structural protein encoded by the CHIKV RNA genome, is able to translocate to the host cell nucleolus. In encephalitic alphaviruses, nuclear translocation induces host cell transcriptional shutoff; however, the role of capsid...
Topics
Join the communities discussing this publication.