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Article

Attenuation of neurovirulence of chikungunya virus by a single amino acid mutation in viral E2 envelope protein.

Journal of biomedical science - 17 Jan 2024

Chen Huixin, Phuektes Patchara, Yeo Li Sze, Wong Yi Hao, Lee Regina Ching Hua, Yi Bowen, Hou Xinjun, Liu Sen, Cai Yu, Chu Justin Jang Hann

Abstract excerpt

BACKGROUND: Chikungunya virus (CHIKV) has reemerged as a major public health concern, causing chikungunya fever with increasing cases and neurological complications. METHODS: In the present study, we investigated a low-passage human isolate of the East/ Central/South African (ECSA) lineage of CHIKV strain LK(EH)CH6708, which exhibited a mix of small and large viral plaques. The small and large plaque variants...

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Identifiers

PMID: 38229040
DOI: 10.1186/s12929-024-00995-x
PMCID: PMC10792792

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