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A structural and functional analysis of opal stop codon translational readthrough during Chikungunya virus replication

20 Oct 2023

Abstract excerpt

species mosquitoes. The CHIKV single-stranded positive-sense RNA genome contains two open reading frames, coding for the non-structural (nsP) and structural proteins of the virus. The non-structural polyprotein precursor is proteolytically cleaved to generate nsP1-4. Intriguingly, most isolates of CHIKV (and other alphaviruses) possess an opal stop codon close to the 3' end of the nsP3 coding sequence and...

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PMID: 37862073
DOI: 10.1099/jgv.0.001909

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