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Article

Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness.

Journal of virology - 1 Aug 2017

Mounce Bryan C, Cesaro Teresa, Vlajnić Lea, Vidiņa Anna, Vallet Thomas, Weger-Lucarelli James, Passoni Gabriella, Stapleford Kenneth A, Levraud Jean-Pierre, Vignuzzi Marco

Abstract excerpt

Polyamines, which are small positively charge molecules present in all cells, play important roles in the replication of DNA and RNA viruses. Chikungunya virus (CHIKV) relies on polyamines for translation of the viral genome upon viral entry, and pharmacological depletion of polyamines limits viral replication. However, the potential development of antiviral resistance necessitates a better understanding of how...

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PMID: 28539441
DOI: 10.1128/JVI.00344-17
PMCID: PMC5512238

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