Article
Local protein dynamics during microvesicle exocytosis in neuroendocrine cells.
Molecular biology of the cell - 1 Aug 2018
Somasundaram Agila, Taraska Justin W
Abstract excerpt
Calcium-triggered exocytosis is key to many physiological processes, including neurotransmitter and hormone release by neurons and endocrine cells. Dozens of proteins regulate exocytosis, yet the temporal and spatial dynamics of these factors during vesicle fusion remain unclear. Here we use total internal reflection fluorescence microscopy to visualize local protein dynamics at single sites of exocytosis of...
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