Article

Mesolimbic opioid-dopamine interaction is disrupted in obesity but recovered by weight loss following bariatric surgery

2020-12-11

Abstract excerpt

<h4>Background</h4> Obesity is a growing burden to health and economy worldwide. Obesity is associated with central μ-opioid receptor (MOR) downregulation, and the interaction between MOR and dopamine D 2 receptor (D 2 R) system in the ventral striatum is disrupted among obese subjects. Weight loss recovers MOR function, but it remains unknown whether it also recovers aberrant opioid-dopamine interaction. Here...

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Literature Corpus work: c9e5cba8-7c16-5b69-bb0c-2b85dc787dde
DOI: 10.1101/2020.12.10.418764

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