Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.

doi:10.1161/CIRCULATIONAHA.122.061451

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Article

Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.

Circulation - 21 Mar 2023

Small Aeron M, Peloso Gina M, Linefsky Jason, Aragam Jayashri, Galloway Ashley, Tanukonda Vidisha, Wang Lu-Chen, Yu Zhi, Sunitha Selvaraj Margaret, Farber-Eger Eric H, Baker Michael T, Setia-Verma Shefali, Lee Simon S K, Preuss Michael, Ritchie Marylyn D, Damrauer Scott M, Rader Daniel J, Wells Quinn S, Loos Ruth, Lubitz Steven A, Thanassoulis George, Cho Kelly, Wilson Peter W F, Natarajan Pradeep, O'Donnell Christopher J

Abstract excerpt

BACKGROUND: Calcific aortic stenosis (CAS) is the most common valvular heart disease in older adults and has no effective preventive therapies. Genome-wide association studies (GWAS) can identify genes influencing disease and may help prioritize therapeutic targets for CAS. METHODS: We performed a GWAS and gene association study of 14 451 patients with CAS and 398 544 controls in the Million Veteran Program....

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PMID: 36802703
DOI: 10.1161/CIRCULATIONAHA.122.061451
PMCID: PMC10806851

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