Article
Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.
JAMA cardiology - 1 Jun 2020
Chen Hao Yu, Cairns Benjamin J, Small Aeron M, Burr Hannah A, Ambikkumar Athithan, Martinsson Andreas, Thériault Sébastien, Munter Hans Markus, Steffen Brian, Zhang Richard, Levinson Rebecca T, Shaffer Christian M, Rong Jian, Sonestedt Emily, Dufresne Line, Ljungberg Johan, Näslund Ulf, Johansson Bengt, Ranatunga Dilrini K, Whitmer Rachel A, Budoff Matthew J, Nguyen Albert, Vasan Ramachandran S, Larson Martin G, Harris William S, Damrauer Scott M, Stark Ken D, Boekholdt S Matthijs, Wareham Nicholas J, Pibarot Philippe, Arsenault Benoit J, Mathieu Patrick, Gudnason Vilmundur, O'Donnell Christopher J, Rotter Jerome I, Tsai Michael Y, Post Wendy S, Clarke Robert, Söderberg Stefan, Bossé Yohan, Wells Quinn S, Smith J Gustav, Rader Daniel J, Lathrop Mark, Engert James C, Thanassoulis George
Abstract excerpt
Importance: Aortic stenosis (AS) has no approved medical treatment. Identifying etiological pathways for AS could identify pharmacological targets. Objective: To identify novel genetic loci and pathways associated with AS. Design, Setting, and Participants: This genome-wide association study used a case-control design to evaluate 44 703 participants (3469 cases of AS) of self-reported European ancestry from the...
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