Novel Polygenic Risk Score and Established Clinical Risk Factors for Risk Estimation of Aortic Stenosis.

doi:10.1001/jamacardio.2024.0011

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Article

Novel Polygenic Risk Score and Established Clinical Risk Factors for Risk Estimation of Aortic Stenosis.

JAMA cardiology - 1 Apr 2024

Small Aeron M, Melloni Giorgio E M, Kamanu Frederick K, Bergmark Brian A, Bonaca Marc P, O'Donoghue Michelle L, Giugliano Robert P, Scirica Benjamin M, Bhatt Deepak, Antman Elliott M, Raz Itamar, Wiviott Stephen D, Truong Buu, Wilson Peter W F, Cho Kelly, O'Donnell Christopher J, Braunwald Eugene, Lubitz Steve A, Ellinor Patrick, Peloso Gina M, Ruff Christian T, Sabatine Marc S, Natarajan Pradeep, Marston Nicholas A

Abstract excerpt

Importance: Polygenic risk scores (PRSs) have proven to be as strong as or stronger than established clinical risk factors for many cardiovascular phenotypes. Whether this is true for aortic stenosis remains unknown. Objective: To develop a novel aortic stenosis PRS and compare its aortic stenosis risk estimation to established clinical risk factors. Design, Setting, and Participants: This was a longitudinal...

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PMID: 38416462
DOI: 10.1001/jamacardio.2024.0011
PMCID: PMC10902779

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