Rare Genetic Variants in LDLR, APOB, and PCSK9 Are Associated With Aortic Stenosis.

Abstract excerpt

BACKGROUND: Despite a proposed causal role for LDL-C (low-density lipoprotein cholesterol) in aortic stenosis (AS), randomized controlled trials of lipid-lowering therapy failed to prevent severe AS. We aimed to assess the impact on AS and peak velocity across the aortic valve conferred by lifelong alterations in LDL-C levels mediated by protein-disrupting variants in 3 clinically significant genes for LDL...

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• Aged
• Aortic Valve
• Aortic Valve Stenosis
• Apolipoprotein B-100
• Cholesterol, LDL