Article
Tumor-associated DNA mutation detection in individuals undergoing colonoscopy.
Cancer medicine - 1 Jan 2018
Fleshner Phillip, Braunstein Glenn D, Ovsepyan Gayane, Tonozzi Theresa R, Kammesheidt Anja
Abstract excerpt
The majority of colorectal cancers (CRC) harbor somatic mutations and epigenetic modifications in the tumor tissue, and some of these mutations can be detected in plasma as circulating tumor DNA (ctDNA). Precancerous colorectal lesions also contain many of these same mutations. This study examined plasma for ctDNA from patients undergoing a screening or diagnostic colonoscopy to determine the sensitivity and...
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