Article
Mutation-Agnostic Detection of Colorectal Cancer Using Liquid Biopsy-Based Methylation-Specific Signatures.
The oncologist - 6 Apr 2023
Gouda Mohamed A, Duose Dzifa Y, Lapin Morten, Zalles Stephanie, Huang Helen J, Xi Yuanxin, Zheng Xiaofeng, Aldesoky Amira I, Alhanafy Alshimaa M, Shehata Mohamed A, Wang Jing, Kopetz Scott, Meric-Bernstam Funda, Wistuba Ignacio I, Luthra Rajyalakshmi, Janku Filip
Abstract excerpt
Detection of methylation patterns in circulating tumor DNA (ctDNA) can offer a novel approach for cancer diagnostics given the unique signature for each tumor type. We developed a next-generation sequencing (NGS)-based assay targeting 32 CpG sites to detect colorectal cancer-specific ctDNA. NGS was performed on bisulfite-converted libraries and status dichotomization was done using median methylation ratios at...
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