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Article

Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia.

Haematologica - 1 Feb 2018

Plešingerová Hana, Janovská Pavlína, Mishra Archana, Smyčková Lucie, Poppová Lucie, Libra Antonín, Plevová Karla, Ovesná Petra, Radová Lenka, Doubek Michael, Pavlová Šárka, Pospíšilová Šárka, Bryja Vítězslav

Abstract excerpt

Chronic lymphocytic leukemia is a disease with up-regulated expression of the transmembrane tyrosine-protein kinase ROR1, a member of the Wnt/planar cell polarity pathway. In this study, we identified COBLL1 as a novel interaction partner of ROR1. COBLL1 shows clear bimodal expression with high levels in chronic lymphocytic leukemia patients with mutated IGHV and approximately 30% of chronic lymphocytic leukemia...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Receptor Tyrosine Kinase-like Orphan Receptors

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Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 29122990
DOI: 10.3324/haematol.2017.178699
PMCID: PMC5792276

Genes

ROR1
CCL19
CXCL12
SYK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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