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Article

Targeting ROR1 identifies new treatment strategies in hematological cancers

13 Apr 2017

Abstract excerpt

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR receptor family consisting of two closely related type I transmembrane proteins ROR1 and ROR2. Owing to mutations in their canonical motifs required for proper kinase activity, RORs are classified as pseudokinases lacking detectable catalytic activity. ROR1 stands out for its selective and high expression in numerous blood and solid...

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PMID: 28408486
DOI: 10.1042/bst20160272

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