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Article

COBLL1, LPL and ZAP70 expression defines prognostic subgroups of chronic lymphocytic leukemia patients with high accuracy and correlates with IGHV mutational status.

Leukemia & lymphoma - 1 Jan 2017

Plesingerova Hana, Librova Zuzana, Plevova Karla, Libra Antonin, Tichy Boris, Skuhrova Francova Hana, Vrbacky Filip, Smolej Lukas, Mayer Jiri, Bryja Vitezslav, Doubek Michael, Pospisilova Sarka

Abstract excerpt

The clinical course of chronic lymphocytic leukemia (CLL) is highly variable. Patients with unmutated IGHV (U-CLL) usually progress rapidly, whereas patients with mutated IGHV (M-CLL) have a more indolent disease. The expression of several genes correlates closely with the IGHV mutational status and could be used to assess prognosis in CLL. We analyzed the prognostic relevance of COBLL1, LPL, and ZAP70 gene...

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Share to Immunoglobulin Heavy Chains
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Lipoprotein Lipase

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Source

Identifiers

PMID: 27185377
DOI: 10.1080/10428194.2016.1180690

Genes

LPL
ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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