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Article

A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status.

Genome biology - 7 Sept 2015

Sood Sanjana, Gallagher Iain J, Lunnon Katie, Rullman Eric, Keohane Aoife, Crossland Hannah, Phillips Bethan E, Cederholm Tommy, Jensen Thomas, van Loon Luc J C, Lannfelt Lars, Kraus William E, Atherton Philip J, Howard Robert, Gustafsson Thomas, Hodges Angela, Timmons James A

Abstract excerpt

BACKGROUND: Diagnostics of the human ageing process may help predict future healthcare needs or guide preventative measures for tackling diseases of older age. We take a transcriptomics approach to build the first reproducible multi-tissue RNA expression signature by gene-chip profiling tissue from sedentary normal subjects who reached 65 years of age in good health. RESULTS: One hundred and fifty probe-sets form...

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Identifiers

PMID: 26343147
DOI: 10.1186/s13059-015-0750-x
PMCID: PMC4561473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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