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Chimeric antigen receptor transduced T cells: Tuning up for the next generation

9 Nov 2017

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy has recently achieved impressive clinical outcome in patients with CD19-positive hematologic malignancies. Extrapolation of CAR T cell treatment to solid tumors, however, has not yet yielded similar results. This might be due to intrinsic causes, e.g. insufficient CAR T cell activation or CAR toxicity as well as extrinsic factors displaying an unfavorable tumor...

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PMID: 29119551
DOI: 10.1002/ijc.31147

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