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Article

Development of novel avenues to overcome challenges facing CAR T cells.

Translational research : the journal of laboratory and clinical medicine - 1 Sept 2017

Kim Soyeon, Moon Edmund K

Abstract excerpt

There has been dramatic success in treating patients with adoptive transfer of autologous T cells genetically modified to express a chimeric antigen receptor redirecting them to the antigen CD19. Despite this success, the application of chimeric antigen receptor T-cell therapy in solid malignancies has encountered many challenges that need to be overcome if similar success across other cancers is to become a...

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Identifiers

PMID: 28648487
DOI: 10.1016/j.trsl.2017.05.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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