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Article

Novel method for rapid fluorescence in-situ hybridization of ALK rearrangement using non-contact alternating current electric field mixing.

Scientific reports - 8 Nov 2017

Fujishima Satoshi, Imai Kazuhiro, Nakamura Ryuta, Nanjo Hiroshi, Saito Yoshitaro, Saito Hajime, Terata Kaori, Sato Yusuke, Motoyama Satoru, Akagami Yoichi, Minamiya Yoshihiro

Abstract excerpt

Echinoderm microtubule-associated protein-like 4 gene and anaplastic lymphoma kinase gene (EML4-ALK) rearrangement is a key driver mutation in non-small cell lung cancer (NSCLC). Although Break-Apart ALK fluorescence in situ hybridization (FISH) is a reliable diagnostic method for detecting ALK gene rearrangement, it is too costly and time-consuming for use as a routine screening test. Our aim was to evaluate the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29118432
DOI: 10.1038/s41598-017-15515-1
PMCID: PMC5678187

Genes

ALK
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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