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Article

Concordance of IHC, FISH and RT-PCR for EML4-ALK rearrangements.

1 Apr 2014

Abstract excerpt

The echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) has emerged as the second most important driver oncogene in lung cancer and the first targetable fusion oncokinase to be identified in 4-6% of lung adenocarcinomas. Crizotinib, along with a diagnostic test-the Vysis ALK Break Apart fluorescence in situ hybridization (FISH) Probe Kit-is approved for the treatment of ALK...

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PMID: 25806283
DOI: 10.3978/j.issn.2218-6751.2014.02.02

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