Article
Development of a Novel One-Step Automated Rapid in situ Hybridization for Anaplastic Lymphoma Kinase Rearrangement Using Non-Contact Alternating-Current Electric-Field Mixing.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2020
Imai Kazuhiro, Takashima Shinogu, Fujishima Satoshi, Matsuo Tsubasa, Watanabe Shin-Nosuke, Nanjo Hiroshi, Akagami Yoichi, Nakamura Ryuta, Terata Kaori, Wakita Akiyuki, Sato Yusuke, Motoyama Satoru, Minamiya Yoshihiro
Abstract excerpt
Echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase (ALK) fusion gene rearrangement is a key driver mutation in non-small cell lung cancer (NSCLC). Although Break-Apart ALK fluorescence in situ hybridization (FISH) is a reliable diagnostic method for detecting ALK gene rearrangement, it is also costly and time-consuming to use as a routine screening test. Our aim was to evaluate the...
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