Article
ALK FISH patterns and the detection of ALK fusions by next generation sequencing in lung adenocarcinoma.
Oncotarget - 13 Dec 2016
Dacic Sanja, Villaruz Liza C, Abberbock Shira, Mahaffey Alyssa, Incharoen Pimpin, Nikiforova Marina N
Abstract excerpt
Break-apart ALK FISH probe is the FDA approved approach for detection of ALK rearrangements in lung carcinoma patients who may benefit from ALK kinase inhibitors. The FISH assay can be technically challenging and difficult to interpret. ALK immunohistochemistry and next generation sequencing have been proposed as alternative approaches. In this study, we compared various ALK -FISH patterns to next -generation...
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