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Article

Chromogenic in situ hybridization is a reliable assay for detection of ALK rearrangements in adenocarcinomas of the lung.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2013

Schildhaus Hans-Ulrich, Deml Karl-Friedrich, Schmitz Katja, Meiboom Maren, Binot Elke, Hauke Sven, Merkelbach-Bruse Sabine, Büttner Reinhard

Abstract excerpt

Reliable detection of anaplastic lymphoma kinase (ALK) rearrangements is a prerequisite for personalized treatment of lung cancer patients, as ALK rearrangements represent a predictive biomarker for the therapy with specific tyrosine kinase inhibitors. Currently, fluorescent in situ hybridization (FISH) is considered to be the standard method for assessing formalin-fixed and paraffin-embedded tissue for ALK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23743932
DOI: 10.1038/modpathol.2013.95

Genes

CISH
ALK
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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