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Article

ALK testing in lung adenocarcinoma: technical aspects to improve FISH evaluation in daily practice.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2015

Martin Vittoria, Bernasconi Barbara, Merlo Elisabetta, Balzarini Piera, Vermi William, Riva Alice, Chiaravalli Anna Maria, Frattini Milo, Sahnane Nora, Facchetti Fabio, Mazzucchelli Luca, Sessa Fausto, Tibiletti Maria Grazia

Abstract excerpt

INTRODUCTION: Anaplastic lymphoma kinase (ALK) gene rearrangement characterizes a subgroup of patients with lung adenocarcinoma who may benefit from ALK inhibitors. Fluorescence in situ hybridization (FISH) with a break-apart/split-signal strategy is the gold standard to investigate ALK. The cuto...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anaplastic Lymphoma Kinase

Share to DNA, Neoplasm

Share to Gene Rearrangement

Share to In Situ Hybridization, Fluorescence

Share to Receptor Protein-Tyrosine Kinases

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Source

Identifiers

PMID: 25514802
DOI: 10.1097/JTO.0000000000000444

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25514802-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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