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Article

Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis.

Nature communications - 8 Nov 2017

Hotz Manuel, Nelson W James

Abstract excerpt

Chemotaxis is a specialized form of directed cell migration important for normal development, wound healing, and cancer metastasis. In the social amoeba Dictyostelium discoideum, four signaling pathways act synergistically to maintain directional cell migration. However, it is unknown how these pathways are coordinated in space and time to achieve persistent chemotaxis. Here, we show that the mRNAs and proteins...

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Identifiers

PMID: 29118357
DOI: 10.1038/s41467-017-01536-x
PMCID: PMC5678099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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