Article
Cell speed, persistence and information transmission during signal relay and collective migration.
Journal of cell science - 15 May 2010
McCann Colin P, Kriebel Paul W, Parent Carole A, Losert Wolfgang
Abstract excerpt
Collective migration is a key feature of the social amoebae Dictyostelium discoideum, where the binding of chemoattractants leads to the production and secretion of additional chemoattractant and the relay of the signal to neighboring cells. This then guides cells to migrate collectively in a head-to-tail fashion. We used mutants that were defective in signal relay to elucidate which quantitative metrics of cell...
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