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Article

A Mutation-Based Method for Pinpointing a DNA N6 -Methyladenine Methyltransferase Modification Site at Single Base Resolution.

Chembiochem : a European journal of chemical biology - 2 Jun 2021

Cheng Mohan, Shu Xiao, Cao Jie, Gao Minsong, Xiang Siying, Wang Fengqin, Wang Yizhen, Liu Jianzhao

Abstract excerpt

DNA N6 -methyladenine (6mA) has recently received notable attention due to an increased finding of its functional roles in higher eukaryotes. Here we report an enzyme-assisted chemical labeling method to pinpoint the DNA 6mA methyltransferase (MTase) substrate modification site at single base resolution. A designed allyl-substituted MTase cofactor was applied in the catalytic transfer reaction, and the allyl...

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PMID: 33779011
DOI: 10.1002/cbic.202100088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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