Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria.

Archives of biochemistry and biophysics - 15 Aug 2007

Yeung Catherine K, Adman Elinor T, Rettie Allan E

Abstract excerpt

Impaired conversion of trimethylamine to trimethylamine N-oxide by human flavin containing monooxygenase 3 (FMO3) is strongly associated with primary trimethylaminuria, also known as 'fish-odor' syndrome. Numerous non-synonymous mutations in FMO3 have been identified in patients suffering from this metabolic disorder (e.g., N61S, M66I, P153L, and R492W), but the molecular mechanism(s) underlying the functional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Metabolism, Inborn Errors

Share to Methylamines

Share to Molecular Sequence Data

Share to Oxygenases

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 17531949
DOI: 10.1016/j.abb.2007.04.014
PMCID: PMC2039921

Genes

FMO3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria.PMID 17531949Read ↗

Human flavin-containing monooxygenase form 3: cDNA expression of the enzymes containing amino acid substitutions observed in individuals with trimethylaminuria.Semantic proximity Read ↗

Deleterious mutations in the flavin-containing monooxygenase 3 (FMO3) gene causing trimethylaminuria.Semantic proximity Read ↗

Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria.Semantic proximity Read ↗

Novel variants in outer protein surface of flavin-containing monooxygenase 3 found in an Argentinian case with impaired capacity for trimethylamine N-oxygenation.Semantic proximity Read ↗

Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources.Semantic proximity Read ↗

Trimethylaminuria and a human FMO3 mutation database.Semantic proximity Read ↗

Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria.Semantic proximity Read ↗

Variants in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.Semantic proximity Read ↗

Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.Semantic proximity Read ↗

Genetic polymorphism of the flavin-containing monooxygenase 3 (FMO3) associated with trimethylaminuria (fish odor syndrome): observations from Japanese patients.Semantic proximity Read ↗

Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.Semantic proximity Read ↗

Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.