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Article

Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma.

FEBS open bio - 1 Sept 2021

Ahmadi Mohsen, Eftekhari Kenzerki Maryam, Akrami Seyed Mohammad, Pashangzadeh Salar, Hajiesmaeili Fatemeh, Rahnavard Sahereh, Habibipour Leila, Saffarzadeh Negin, Mousavi Pegah

Abstract excerpt

Hypoxanthine phosphoribosyltransferase (HPRT1), as a salvage pathway enzyme, plays a crucial role in modulating the cell cycle and has been reported to be overexpressed in multiple cancers. Nevertheless, the relationship between the HPRT1 gene and head and neck squamous cell carcinomas (HNSCCs) has not been investigated so far. In this study, we first evaluated the expression and clinical value of HPRT1 mRNA and...

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Source

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Identifiers

PMID: 34231338
DOI: 10.1002/2211-5463.13250
PMCID: PMC8409317

Genes

HPRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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