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Article

p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade

29 Dec 2021

Abstract excerpt

Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies than its HPV-negative counterpart. Here, we show that p16, the clinically used surrogate for HPV positivity, renders cells more sensitive to radiotherapy via a ubiquitin-dependent signaling pathway, linking high levels of this protein to increased activity of the transcription factor SP1, increased HUWE1...

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PMID: 34965932
DOI: 10.1158/0008-5472.can-21-2101

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