Article
DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma.
Oncotarget - 29 Sept 2015
Weaver Alice N, Cooper Tiffiny S, Rodriguez Marcela, Trummell Hoa Q, Bonner James A, Rosenthal Eben L, Yang Eddy S
Abstract excerpt
Patients with human papillomavirus-positive (HPV+) head and neck squamous cell carcinomas (HNSCCs) have increased response to radio- and chemotherapy and improved overall survival, possibly due to an impaired DNA damage response. Here, we investigated the correlation between HPV status and repair of DNA damage in HNSCC cell lines. We also assessed in vitro and in vivo sensitivity to the PARP inhibitor veliparib...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.