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Inhibitor of Differentiation-1 Sustains Mutant KRAS -Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network

18 Dec 2018

Abstract excerpt

Abstract Because of the refractory nature of mutant KRAS lung adenocarcinoma (LUAD) to current therapies, identification of new molecular targets is essential. Genes with a prognostic role in mutant KRAS LUAD have proven to be potential molecular targets for therapeutic development. Here we determine the clinical, functional, and mechanistic role of inhibitor of differentiation-1 (Id1) in mutant KRAS LUAD....

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PMID: 30563891
DOI: 10.1158/0008-5472.can-18-1479

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