Article
A complex association between ABCA7 genotypes and blood lipid levels in Southern Chinese Han patients of sporadic Alzheimer's disease.
Journal of the neurological sciences - 15 Nov 2017
Li Hui, Zhou Jinxia, Yue Zongwei, Feng Li, Luo Zhaohui, Chen Si, Yang Xiaosu, Xiao Bo
Abstract excerpt
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by progressive cognitive decline. It can be divided into familial AD (FAD) and sporadic AD (SAD) based on the family history. Recently dysregulation of cholesterol homeostasis has been implicated in the development of late-onset AD. ATP-binding cassette transporter A7 (ABCA7) gene, regulating the transport of cholesterol, has been...
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