Article
A heuristic method to identify runs of homozygosity associated with reduced performance in livestock.
Journal of animal science - 1 Oct 2017
Howard J T, Tiezzi F, Huang Y, Gray K A, Maltecca C
Abstract excerpt
Although, for the most part, genome-wide metrics are currently used in managing livestock inbreeding, genomic data offer, in principle, the ability to identify functional inbreeding. Here, we present a heuristic method to identify haplotypes contained within a run of homozygosity (ROH) associated with reduced performance. Results are presented for simulated and swine data. The algorithm comprises 3 steps. Step 1...
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