Article
Inbreeding and runs of homozygosity before and after genomic selection in North American Holstein cattle.
BMC genomics - 27 Jan 2018
Forutan Mehrnush, Ansari Mahyari Saeid, Baes Christine, Melzer Nina, Schenkel Flavio Schramm, Sargolzaei Mehdi
Abstract excerpt
BACKGROUND: While autozygosity as a consequence of selection is well understood, there is limited information on the ability of different methods to measure true inbreeding. In the present study, a gene dropping simulation was performed and inbreeding estimates based on runs of homozygosity (ROH), pedigree, and the genomic relationship matrix were compared to true inbreeding. Inbreeding based on ROH was estimated...
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