Article
Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice.
The American journal of pathology - 1 Jan 2018
Yu Dongfang, Saini Yogesh, Chen Gang, Ghio Andrew J, Dang Hong, Burns Kimberlie A, Wang Yang, Davis Richard M, Randell Scott H, Esther Charles R, Paulsen Friedrich, Boucher Richard C
Abstract excerpt
Human subjects with pseudohypoaldosteronism-1 because of loss-of-function mutations in epithelial sodium channel (ENaC) subunits exhibit meibomian gland (MG) dysfunction. A conditional βENaC MG knockout (KO) mouse model was generated to elucidate the pathogenesis of absent ENaC function in the MG and associated ocular surface disease. βENaC MG KO mice exhibited a striking age-dependent, female-predominant MG...
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