Article

Lipid composition determines thermotropic properties of meibum of animals and humans with Meibomian gland disorders

2025-08-29

Abstract excerpt

<h4>ABSTRACT</h4> Meibum – a lipid-rich secretion produced by holocrine Meibomian glands (MG) – plays a central role in maintaining ocular surface homeostasis. Previously, changes in MG lipidomes induced by inactivation of critical genes of meibogenesis, such as Elovl3, Soat1, Awat2, and others, were shown to cause MG-dysfunction- and dry eye-like signs in mice. Here, we describe the impact of the lipid composit...

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Literature Corpus work: 7863649f-51df-52fc-bad8-377097801f8a
DOI: 10.1101/2025.08.25.672195

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