Article

Human meibomian gland organoids to study epithelial homeostasis and dysfunction

2025-06-11

Abstract excerpt

Meibomian glands (MGs) are holocrine glands that secrete lipids to maintain the homeostasis of ocular surface, and their dysfunction leads to dry eye disease. Herein, we established long-term 3D organoid culture for murine and human MGs, which retained the cell lineages and lipid-producing ability. The organoids mimicked the drug treatment responses and generated functional MGs after orthotopic transplantation. In...

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Literature Corpus work: 5cc4a17f-1aa7-5522-8914-5ea39bfc0486
DOI: 10.1101/2025.06.10.658800

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