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Article

Pharmacologic Alteration of Meibum Lipid Composition Alleviates Dry Eye Phenotype in Awat2-/- Mice.

Investigative ophthalmology & visual science - 1 Jun 2026

Widjaja-Adhi Made Airanthi K, Chung Chloe, Lapierre-Landry Maryse, Chao Karina, Lu Eric Y, Swigris Jaclyn, Walczak-Szeffer Anna, Golczak Wiktor, Sayegh Rony R, Jenkins Michael W, Golczak Marcin

Abstract excerpt

Purpose: Meibomian glands (MGs) produce lipids that stabilize the tear film and maintain ocular surface homeostasis. Dysfunction of MG lipid secretion is a major cause of evaporative dry eye (EDE). The purpose of this study was to test whether pharmacologic modulation of meibum lipid biosynthesis could improve the physicochemical properties of meibum and thereby slow the progression of EDE in a mouse model of the...

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PMID: 42307183
DOI: 10.1167/iovs.67.6.34
PMCID: PMC13284920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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