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Article

Functional role of PLCE1 intronic insertion variant associated with susceptibility to esophageal squamous cell carcinoma.

Carcinogenesis - 9 Feb 2018

Wei Lixuan, Shao Mingming, Zhao Yanjie, Zheng Jian, Chu Jiahui, Chang Jiang, Cheng Xinxin, Cui Qionghua, Peng Linna, Luo Yingying, Tan Wenle, Tan Wen, Lin Dongxin, Wu Chen

Abstract excerpt

Genome-wide association studies (GWAS) have consistently identified PLCE1 as esophageal squamous cell carcinoma (ESCC) susceptibility gene; however, the functional role of PLCE1 variants remains to be verified. In this study, we performed fine mapping of the PLCE1 region using our previous ESCC GWAS data and identified 33 additional risk variants in this susceptibility locus. Here, we report the functional...

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Source

Identifiers

PMID: 29106514
DOI: 10.1093/carcin/bgx123

Genes

PLCE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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